Science
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Science
These six advances could change how drugs are delivered
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Special delivery: bacterial couriers are smuggling drugs into cancers
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Drug-delivering particles aim to breach the blood–brain barrier
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Medicines do no good if people don’t take them
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A good drug is useless if it misses its target
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Dose once, treat forever: drugs are being engineered to last much longer
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Nasal vaccines could stop pandemics before they begin
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Drug delivery gets subcellular
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Highly efficient base editing at PCSK9 and normal human embryo development
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Breaking timescales with generative sampling of conformational transitions
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Neocortical long-range inhibition promotes cortical synchrony and sleep
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An operational perturbation proteomics-based virtual cell model
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PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
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Denisovans from southwestern China and their subsistence strategies
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Mobile education builds resilience during shocks in five countries
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Ancient proteins identify various Denisovan remains from Southwest China
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Predicting genome-wide functional constraints with GPN-Star
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Imaging cellular activity across all organs reveals body-wide circuits
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TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
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Anodic Pd membrane H2 extraction enhances thermochemical dehydrogenation
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Integrated signatures define mutational processes in prostate cancer
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TM184C is a GPCR-like regulator of intercellular exchange and autophagy
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Proximity-guided graph learning reveals tumour-associated proximity antigens
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DNA-editing ‘pencils’ probe early human development
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Uniform film formation helps tandem solar cells work better for longer
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Who were the Denisovans? Rich trove of fossils and tools paints new picture
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Combined satellite and news data capture unseen aspects of war
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Phone-based tutoring improves learning during school closures
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Phone-call tutorials improve learning cost-effectively during education emergencies
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Electric charge makes drops of water more destructive
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